Intron 1 factor VIII gene inversion in a population of Italian hemophilia A patients

Bagnall and collegues[1][1] report a technique to investigate an inversion that disrupts the factor VIII ( F8 ) gene and that represents a frequent cause of severe hemophilia A. This large genomic rearrangement, identified for the first time by Brinke et al[2][2] in 2 haemophilic monozygotic twins