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KRAS SNPs are related to colorectal cancer susceptibility and survival in Chinese people
- Source :
- Biomarkers in Medicine. 14:13-22
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Aim: KRAS SNPs may increase KRAS transcription and KRAS levels. SNPs of KRAS 3′UTR can affect carcinoma risk and prognosis. Materials & methods: The rs8720 and rs7960917 in KRAS 3′UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case–control study. Association between SNPs and CRC risk, survival analysis were analyzed by an unconditional logistic regression model, log-rank test, Kaplan–Meier estimation, Cox regression model and one-way analysis of variance. Results & conclusion: The genotype CT of rs8720 was significantly increased risk of CRC, decreased overall survival and event-free survival, and KRAS mRNA and protein expressions were significantly increased in individuals with rs8720 CT, TT genotype. rs8720 may be an important factor in CRC development and prognosis.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Colorectal cancer
Clinical Biochemistry
Single-nucleotide polymorphism
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Internal medicine
Drug Discovery
Genotype
medicine
Carcinoma
neoplasms
Survival analysis
Proportional hazards model
business.industry
Biochemistry (medical)
medicine.disease
digestive system diseases
Chinese people
030104 developmental biology
030220 oncology & carcinogenesis
KRAS
business
Subjects
Details
- ISSN :
- 17520371 and 17520363
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Biomarkers in Medicine
- Accession number :
- edsair.doi...........2061e81bd25ce6053e07c76fa7a61914