Gene Therapy for Sjögren’s Syndrome

Gene therapy has the potential to introduce a new approach to treating Sjogren’s syndrome. In the last 10 years, gene therapy has advanced from preclinical to approved drugs for a diverse set of conditions, including blindness, neurologic disease, and hemophilia. Many aspects of Sjogren’s syndrome are suited to current vectors and promoters. Preclinical studies in animal models of Sjogren’s syndrome have yielded promising results. In this chapter, we will review the current state of gene transfer technology, its applications, different aspects of vector systems applicable in Sjogren’s syndrome, relevant animal models for preclinical studies, and their outcomes as well as future directions for advancement.