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Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3
- Source :
- IUPHAR/BPS Guide to Pharmacology CITE. 2021
- Publication Year :
- 2021
- Publisher :
- Edinburgh University Library, 2021.
-
Abstract
- Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic agents such as organophosphates.
Details
- ISSN :
- 26331020
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- IUPHAR/BPS Guide to Pharmacology CITE
- Accession number :
- edsair.doi...........21748271f1e349fb133f34951200f47b