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Synthesis of Functionalized Bicyclic Compounds Based on 2-(1-Arylethylidene)malononitriles
- Source :
- Russian Journal of Organic Chemistry. 55:1967-1970
- Publication Year :
- 2019
- Publisher :
- Pleiades Publishing Ltd, 2019.
-
Abstract
- New tetrahydroisoquinoline-5,7-dicarbonitrile derivatives have been synthesized by piperazine hydrate-catalyzed reaction of acetoacetanilide with 2-(1-arylethylidene)malononitriles (Knoevenagel condensation products of acetophenones and malononitrile) in aqueous ethanol at room temperature. The product structure was confirmed by NMR spectra and X-ray analysis of 1,6-diamino-4a-methyl-3-oxo-2,8-diphenyl-2,3,4,4a-tetrahydroisoquinoline-5,7-dicarbonitrile.
Details
- ISSN :
- 16083393 and 10704280
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Russian Journal of Organic Chemistry
- Accession number :
- edsair.doi...........21aebebf5bc89e75fcac0d6a15c8f874