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Synthesis and in vitro cytotoxicity of novel 1,4-disubstituted phthalazines
- Source :
- Chinese Chemical Letters. 19:29-32
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Eight novel 1,4-disubstituted phthalazines ( 7 – 14 ) were designed and synthesized. The structures of all the synthesized compounds were confirmed by IR, 1 H NMR, 13 C NMR, MS and elemental analysis. Their in vitro cytotoxicity against cancer cell lines (Bel-7402 and HT-1080) were evaluated by standard MTT assay. Among them, compounds 9 and 11 exhibited more potent cytotoxicity than cisplatin.
Details
- ISSN :
- 10018417
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Chinese Chemical Letters
- Accession number :
- edsair.doi...........22ecd5bcc916c95d1faf4c5d00569bb3
- Full Text :
- https://doi.org/10.1016/j.cclet.2007.11.018