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Total synthesis of pawhuskin C: a directed ortho metalation approach
- Source :
- Tetrahedron Letters. 46:1321-1324
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- The total synthesis of the opioid modulator pawhuskin C has been accomplished in eight steps from methyl 3,5-dihydroxybenzoate. The key step in this sequence is a directed ortho metalation reaction conducted without protection of a benzylic alcohol and thus presumed to involve a formal dianion intermediate.
Details
- ISSN :
- 00404039
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........231183cd128ec7f32ecb2926dc81ae5b