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P221 Cerebellar theta burst stimulation modulates the neural activity of interconnected parietal and motor areas
- Source :
- Clinical Neurophysiology. 128:e121-e122
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Question Voluntary movement control and execution are regulated by the influence of the cerebellar output over different interconnected cortical areas, through dentato-thalamo connections. However, in humans, connectivity and plasticity dynamics of the cerebellar-thalamo-cortical connections have been only indirectly explored. Methods In the present study we applied in a group of healthy volunteers transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to directly assess the effects of three theta-burst stimulation (TBS) protocols (intermittent, continuous and sham) over the primary motor cortex (M1) and the posterior parietal cortex (PPC) of the contralateral hemisphere. Results We found a TBS-dependent bidirectional modulation over TMS-evoked activity; specifically, cTBS increased whereas iTBS decreased activity between 100 and 200 ms after TMS, in a similar manner over both M1 and PPC areas. On the oscillatory domain, TBS induced specific changes over M1 natural frequencies of oscillation: TMS-evoked alpha activity was decreased by cTBS whereas beta activity was enhanced by iTBS. No effects were observed after sham stimulation. Conclusions Our data provide novel evidence showing that the cerebellum exerts its control on the cortex likely by impinging on specific set of interneurons dependent on GABA-ergic activity. We show that cerebellar TBS modulates cortical excitability of distant interconnected cortical areas by acting through common temporal, spatial and frequency domains. Download : Download high-res image (481KB) Download : Download full-size image Download : Download high-res image (558KB) Download : Download full-size image
- Subjects :
- Cerebellum
medicine.diagnostic_test
medicine.medical_treatment
05 social sciences
CTBS
Posterior parietal cortex
Stimulation
Electroencephalography
Sensory Systems
Transcranial magnetic stimulation
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
nervous system
Neurology
Physiology (medical)
Cortex (anatomy)
0502 economics and business
medicine
050211 marketing
Neurology (clinical)
Primary motor cortex
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 128
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi...........23825df016d60b400d9864cb08dc86b8