Efficacy of Panobinostat (LBH589) in Multiple Myeloma Cell Lines and In Vivo Mouse Model: Tumor-Specific Cytotoxicity and Protection of Bone Integrity in Multiple Myeloma

Authors :: Wenlin Shao
Yung-Mae Yao
Minying Pu
Peter Atadja
Jane Cheng
Joseph D. Growney
Andrew Spencer
Kenneth C. Anderson
Colleen Kowal
Christine Miller
Stephen Fawell
Brant Firestone
Youzhen Wang
Joseph Eckman
Jesús F. San Miguel
Source :: Blood. 110:1510-1510
Publication Year :: 2007
Publisher :: American Society of Hematology, 2007.
Abstract: Panobinostat (LBH589) is a highly potent oral pan-deacetylase (DAC) inhibitor currently undergoing clinical development in hematologic and solid malignancies. Here we report the effects of panobinostat on multiple myeloma (MM) cells in vitro and in a murine xenograft model in vivo. Panobinostat exhibited potent cytotoxic activity (IC50

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