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Acute promyelocytic leukemia in a child with reticulin fibrosis
- Source :
- Journal of Hematopathology. 13:269-273
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Reactive myelofibrosis (MF) may be associated with infectious, inflammatory, or neoplastic conditions. Extensive myelofibrosis and indolent course are frequent in acute megakaryoblastic leukemia, but these findings are rarely reported in acute promyelocytic leukemia (APL). Patients with neoplastic disorders associated with MF are reported to have an inferior outcome. However, the effect of this association is not apparent in APL patients. This report presents a case of APL in a pediatric patient in association with significant reticulin fibrosis and osteosclerosis. The case highlights that fibrosis in the marrow can make it more challenging to diagnose acute leukemia. The PML-RARA transcripts can be present with subtle clinical or hematological findings, emphasizing the importance of molecular studies in unexplained cytopenias. Furthermore, in the case of APL, as opposed to other myeloid neoplasms, fibrosis does not appear to be associated with a worse prognosis and can resolve after treatment.
- Subjects :
- Acute promyelocytic leukemia
Oncology
medicine.medical_specialty
Histology
Myeloid
Pathology and Forensic Medicine
03 medical and health sciences
Osteosclerosis
Acute megakaryoblastic leukemia
0302 clinical medicine
immune system diseases
Fibrosis
hemic and lymphatic diseases
Internal medicine
medicine
Myelofibrosis
neoplasms
Acute leukemia
Hematology
business.industry
medicine.disease
medicine.anatomical_structure
030220 oncology & carcinogenesis
business
030215 immunology
Subjects
Details
- ISSN :
- 18655785 and 18689256
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Hematopathology
- Accession number :
- edsair.doi...........2509540a4f8e565b6de6134d81e29167