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Two new cadinane sesquiterpenes and one new lignan from Abelmoschus moschatus subsp. tuberosus and their α-glucosidase inhibitory activity
- Source :
- Phytochemistry Letters. 41:1-5
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Two new cadinane sesquiterpenes, cadinoschanes A and B (1 and 2), one new norlignan, lignanoschane A (6) along with seven known compounds, hibiscone B (3), 7β-O-β-glucopyranosyl bombaxone (4), 2,7β,8β-trihydroxy trans-calamenene 7-O-β-D-glucopyranoside (5), clemastanin A (7), (−)-3,4,3′,4′-tetrahydroxy-9,7′β-epoxylignano-7β,9′-lactone (8), N-trans-feruloyl tyramine (9), and methyl (3R)-3-[(3R)-3-{(3R)-3-hydroxybutanoyloxy} butanoyloxy} butanoate (10) were isolated from Abelmoschus moschatus subsp. tuberosus (Span.) Borss. Waalk. Their structures were determined on the basis of extensive spectroscopic methods, including 1D, 2D NMR and MS data and comparing experimental CD with theoretical CD calculations. Compounds 3 and 9 showed significant α-glucosidase inhibitory activity with IC50 values of 121.7 ± 3.9 and 4.3 ± 0.5 μg/mL, respectively, compared to those of a positive control, acarbose with IC50 value of 183.5 ± 12.2 μg/mL.
- Subjects :
- Lignan
biology
010405 organic chemistry
Stereochemistry
Plant Science
Tyramine
biology.organism_classification
01 natural sciences
Biochemistry
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
chemistry
Ic50 values
medicine
Abelmoschus moschatus
Agronomy and Crop Science
Two-dimensional nuclear magnetic resonance spectroscopy
α glucosidase inhibitory
IC50
Biotechnology
Acarbose
medicine.drug
Subjects
Details
- ISSN :
- 18743900
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Phytochemistry Letters
- Accession number :
- edsair.doi...........2668e990278486f7710320f924e56417
- Full Text :
- https://doi.org/10.1016/j.phytol.2020.10.013