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Two new cadinane sesquiterpenes and one new lignan from Abelmoschus moschatus subsp. tuberosus and their α-glucosidase inhibitory activity

Authors :
Duong Thi Dung
Bui Huu Tai
Phan Van Kiem
Pham Tuan Anh
Nguyen Xuan Nhiem
Do Quyen
Hoang Viet Dung
Hoang Quynh Hoa
Do Thi Thao
Source :
Phytochemistry Letters. 41:1-5
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Two new cadinane sesquiterpenes, cadinoschanes A and B (1 and 2), one new norlignan, lignanoschane A (6) along with seven known compounds, hibiscone B (3), 7β-O-β-glucopyranosyl bombaxone (4), 2,7β,8β-trihydroxy trans-calamenene 7-O-β-D-glucopyranoside (5), clemastanin A (7), (−)-3,4,3′,4′-tetrahydroxy-9,7′β-epoxylignano-7β,9′-lactone (8), N-trans-feruloyl tyramine (9), and methyl (3R)-3-[(3R)-3-{(3R)-3-hydroxybutanoyloxy} butanoyloxy} butanoate (10) were isolated from Abelmoschus moschatus subsp. tuberosus (Span.) Borss. Waalk. Their structures were determined on the basis of extensive spectroscopic methods, including 1D, 2D NMR and MS data and comparing experimental CD with theoretical CD calculations. Compounds 3 and 9 showed significant α-glucosidase inhibitory activity with IC50 values of 121.7 ± 3.9 and 4.3 ± 0.5 μg/mL, respectively, compared to those of a positive control, acarbose with IC50 value of 183.5 ± 12.2 μg/mL.

Details

ISSN :
18743900
Volume :
41
Database :
OpenAIRE
Journal :
Phytochemistry Letters
Accession number :
edsair.doi...........2668e990278486f7710320f924e56417
Full Text :
https://doi.org/10.1016/j.phytol.2020.10.013