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Orally administered heat-killed Lactobacillus gasseri TMC0356 alters respiratory immune responses and intestinal microbiota of diet-induced obese mice
- Source :
- Journal of Applied Microbiology. 113:155-162
- Publication Year :
- 2012
- Publisher :
- Oxford University Press (OUP), 2012.
-
Abstract
- Aims: To investigate the influence of heat-killed Lactobacillus gasseri TMC0356 on changes in respiratory immune function and intestinal microbiota in a diet-induced obese mouse model. Methods and Results: Male C57BL/6J mice were fed a high-fat diet for 16 weeks. After 8 weeks, the high-fat-diet-induced obese mice (DIO mice) were randomly divided into two 0067roups, the DIO and DIO0356 groups. DIO0356 group mice were orally fed with heat-killed TMC0356 every day for 8 weeks, while DIO group mice were exposed to 0·85% NaCl over the same time period as controls. After intervention, the pulmonary mRNA expression of cytokines and other immune molecules in DIO0356 mice compared to those in DIO group mice was significantly increased (P
- Subjects :
- medicine.medical_specialty
Lung
biology
Respiratory infection
General Medicine
Lactobacillus gasseri
biology.organism_classification
Applied Microbiology and Biotechnology
Endocrinology
Immune system
medicine.anatomical_structure
Immunity
Oral administration
Internal medicine
Immunology
medicine
Respiratory system
Diet-induced obese
Biotechnology
Subjects
Details
- ISSN :
- 13645072
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Microbiology
- Accession number :
- edsair.doi...........26958279ea4b9ef4c71785c3dbf79076
- Full Text :
- https://doi.org/10.1111/j.1365-2672.2012.05316.x