132 Intermittent dosing of the MEK inhibitor, GDC-0973, and the PI3K inhibitor, GDC-0941, results in prolonged accumulation of Bim and causes strong tumor growth inhibition in vivo

Authors :: Leanne Berry
Kenneth D. Rice
Mark Merchant
Christine Orr
Hartmut Koeppen
Klaus P. Hoeflich
Marcia Belvin
Jocelyn Chan
D. den Otter
Lori Friedman
Source :: European Journal of Cancer Supplements. 8:48
Publication Year :: 2010
Publisher :: Elsevier BV, 2010.

Subjects :: Cancer Research
Intermittent dosing
Oncology
In vivo
Chemistry
Tumor growth inhibition
Pharmacology
MEK Inhibitor GDC-0973
PI3K/AKT/mTOR pathway

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