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Prognostic Value of Combination of Hemodynamic Parameters in Asymptomatic Aortic Valve Stenosis—The COFRASA/GENERAC Study
- Source :
- Structural Heart. 1:75-80
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background: Whether risk-stratification in aortic valve stenosis (AS) should rely on a single hemodynamic parameter or a combination of hemodynamic parameters is still debated. We aimed to evaluate the prognostic value of mean pressure gradient (MPG), aortic valve area (AVA), and the dimensionless index (DI) in patients with AS and to test whether their combination provides additional prognostic information.Methods: We enrolled 319 asymptomatic patients with AS (90 mild, 173 moderate, and 56 severe AS). All patients were prospectively followed on a yearly basis and AS-related events (sudden death, heart failure, or new onset of AS-related symptoms) were collected.Results: After a mean follow-up of 3.1±1.7 years, an AS-related event occurred in 84 patients (26%). When considered in isolation, after adjustment for age, sex, history of coronary artery disease, valve anatomy, and left ventricular ejection fraction, each parameter (MPG, AVA, and DI) independently predicted the occurrence of AS-related ...
- Subjects :
- medicine.medical_specialty
Ejection fraction
business.industry
Hemodynamics
030204 cardiovascular system & hematology
medicine.disease
Sudden death
Asymptomatic
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Aortic valve area
Aortic valve stenosis
Internal medicine
Heart failure
medicine
Cardiology
030212 general & internal medicine
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 24748706
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Structural Heart
- Accession number :
- edsair.doi...........26d4e2be88578d699a621271ef55458e