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Enantioselective formal synthesis of (−)-aurantioclavine using Pd-catalyzed cascade cyclization and organocatalytic asymmetric aziridination
- Source :
- Tetrahedron Letters. 59:760-762
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- The enantioselective formal synthesis of (−)-aurantioclavine is described. The core tricyclic skeleton was synthesized using a Pd-catalyzed Heck insertion–allylic amination cascade. The stereocenter was constructed by a highly enantioselective organocatalytic asymmetric aziridination reaction.
Details
- ISSN :
- 00404039
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........26e6e36f3fca4b5b61671335ebc38918