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Old dogs and new tricks: Defective peripheral regulatory T cell generation in aged mice
- Source :
- European Journal of Immunology. 43:2534-2537
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Tolerance is a developmentally acquired property of the vertebrate immune system, in part ensured by regulatory CD4+ lymphocytes (Treg cells) expressing the Foxp3 transcription factor. Recent work has shown that thymic emigrants are the preferential source of peripherally generated Treg cells. A new report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2013. 43: 2598–2604] describes a cell autonomous defect in Foxp3 induction in aged CD4+ cells in mice. Immune homeostasis becomes progressively less robust as ontogeny gives way to aging, and a key feature of senescence is thymic involution and the impaired T-cell turnover that follows. In this Commentary, we discuss the implications of these recent findings for our understanding of the induction of tolerance to peripheral antigens in aging.
Details
- ISSN :
- 00142980
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- European Journal of Immunology
- Accession number :
- edsair.doi...........2701daccf05d9a354ce309f5f7aa9426