ChemInform Abstract: Synthesis of 3-Substituted 5-(2-Thienyl)isoxazoles

Thienyl trichloroallyl ketone (I), a synthetic equivalent of β-chlorovinyl ketones, reacts with hydroxylamine to an intermediate dichloromethyl-substituted isoxazole which upon reaction with a second hydroxylamine molecule affords the hydoxyiminomethyl-substituted isoxazole (II).