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Preventive Effects of Nicorandil Against Contrast-Induced Nephropathy in Patients With Moderate Renal Insufficiency Undergoing Percutaneous Coronary Intervention
- Source :
- Angiology. 71:183-188
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- We investigated the preventive effect of nicorandil on contrast-induced nephropathy (CIN) in patients with moderate renal insufficiency undergoing percutaneous coronary intervention (PCI). A total of 250 patients with a creatinine clearance (crCl) ≤60 mL/min undergoing PCI were randomly assigned to either a nicorandil group (nicorandil 10 mg 3 times/d and hydration; n = 125) or a control group (hydration only; n = 125). The first end point was the incidence of CIN defined as an increase in serum creatinine (Scr) levels by ≥0.5 mg/dL or ≥25% within 72 hours after exposure to the contrast medium. The secondary end points were (1) changes in Scr, blood urea nitrogen, and crCl and (2) the incidence of major adverse events during hospitalization. The incidence of CIN was 1.6% (2/125) in the nicorandil group and 9.6% (12/125) in the control group ( P = .011). There was no obvious difference in the incidence of major adverse events during hospitalization between the nicorandil and the control group (4.0% vs 4.8%, P = 1.000). Multivariate logistic regression analysis showed that nicorandil was a protective factor for CIN (odds ratios = 0.126, 95% confidence interval: −19.996 to −0.932, P = .012). Prophylactic administration of nicorandil may prevent against CIN in patients with moderate renal insufficiency undergoing PCI.
- Subjects :
- medicine.medical_specialty
Creatinine
business.industry
medicine.medical_treatment
Urology
Contrast-induced nephropathy
Percutaneous coronary intervention
Renal function
030204 cardiovascular system & hematology
medicine.disease
Nephropathy
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
chemistry
Conventional PCI
cardiovascular system
medicine
030212 general & internal medicine
Cardiology and Cardiovascular Medicine
Nicorandil
business
Blood urea nitrogen
medicine.drug
Subjects
Details
- ISSN :
- 19401574 and 00033197
- Volume :
- 71
- Database :
- OpenAIRE
- Journal :
- Angiology
- Accession number :
- edsair.doi...........274b06405c4922d917f9ece7e1acd8ff