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Leptin regulates proinflammatory immune responses
- Source :
- The FASEB Journal. 12:57-65
- Publication Year :
- 1998
- Publisher :
- Wiley, 1998.
-
Abstract
- Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality. Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity. It is unclear, however, whether defective leptin-dependent signal transduction directly promotes any of the conditions that frequently complicate obesity. Abnormalities in tumor necrosis factor α expression have been noted in each of the above comorbid conditions, so leptin deficiency could promote these complications if leptin had immunoregulatory activity. Studies of rodents with genetic abnormalities in leptin or leptin receptors revealed obesity-related deficits in macrophage phagocytosis and the expression of proinflammatory cytokines both in vivo and in vitro. Exogenous leptin up-regulated both phagocytosis and the production of proinflammatory cytokines. These results identify an important and nov...
- Subjects :
- medicine.medical_specialty
Leptin receptor
Leptin Deficiency
business.industry
Leptin
medicine.medical_treatment
digestive, oral, and skin physiology
Biochemistry
Proinflammatory cytokine
Endocrinology
Cytokine
Immune system
Internal medicine
Immunology
Genetics
medicine
Tumor necrosis factor alpha
Interleukin 18
business
Molecular Biology
hormones, hormone substitutes, and hormone antagonists
Biotechnology
Subjects
Details
- ISSN :
- 15306860 and 08926638
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- The FASEB Journal
- Accession number :
- edsair.doi...........282e9b38b3f4a65a54e883058073d817