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Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates

Authors :
Mendi A. Higgins
Jianliang Shi
Lawrence R. Marcin
Yong-Jin Wu
Jason M. Guernon
Fukang Yang
Lorin A. Thompson
Lawrence B. Snyder
Source :
Tetrahedron Letters. 55:2134-2137
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

A series of β-disubstituted N-sulfinyl β-amino isoxazolyl ketones has been prepared by addition of tert-butanesulfinyl ketimines with the n-BuLi-generated enolates of isoxazolyl methyl ketones.

Details

ISSN :
00404039
Volume :
55
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi...........293c93c3d5dffa2f2afa9596a1316b52
Full Text :
https://doi.org/10.1016/j.tetlet.2014.02.053