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We devised a treatment protocol for anaplastic gliomasconsisting of: (a) chemotherapy prior to radiotherapy (b)a second chemotherapy regimen at tumor recurrence (c)repeated surgery whenever possible. 41 Anaplastic Astrocytoma (AA),16 Anaplastic oligoastrocytoma (AOA) and 14 anaplastic oligodendroglioma(AOD) patients were treated. After surgery all patientsreceived 5–6 cycles of carmustine + Cisplatinum chemotherapy.Radiotherapy was started during the last 2–3 cyclesof chemotherapy. 17 patients (30.5%) were reoperated-on atrecurrence. All recurring patients underwent PVC chemotherapy. Atthis moment disease recurred in 56 patients. MedianTTP was 24.5, 38.7 and 58.2 months forAA, AOA and AOD respectively. Median ST was38.8, 71.8 and 73 months. In conclusion oursandwich protocol of prior chemotherapy, overlapping irradiation withsecond chemotherapy and, in favourable cases, a secondsurgical intervention, is of benefit in patients withanaplastic gliomas.