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GW29-e1702 Bepridil a class IV antiarrhythmic agent can block TREK-1 potassium channel

Authors :
M.A. Zhiyong
Zhijie Fu
Na Li
Shanying Huang
Li Li
Yun Zhang
Source :
Journal of the American College of Cardiology. 72:C55
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

The two-pore domain potassium (K2P) channel TREK-1 is recognized as a new and major candidate of cardiac stretch-activated potassium current and play a key role in the pathogenesis of human cardiac arrhythmias and heart failure. However, there is little study about the effect of antiarrhythmic drugs

Details

ISSN :
07351097
Volume :
72
Database :
OpenAIRE
Journal :
Journal of the American College of Cardiology
Accession number :
edsair.doi...........2a85d1f7c1d92ede74e718e6845fb6a9
Full Text :
https://doi.org/10.1016/j.jacc.2018.08.201