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Low-dose diethylhexyl phthalate exposure does not impair the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in mouse mammary glands
- Source :
- Molecular & Cellular Toxicology. 14:143-153
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Di-(2-ethylhexyl) phthalate (DEHP), as an endocrine-disrupting chemical (EDC), is widely used in plasticizer and other productions. Ubiquitous human exposure to DEHP has been proposed to be a potential risk to public health. Developmental exposure to DEHP could alter epigenetic programming and result in adult-onset disease. In this study, we investigated whether DEHP exposure to pregnant mice affected epigenetic changes as a result of increase in breast cancer incidence. Our results showed that the expression of total 143 epigenetics-related genes in mammary gland cells, have no significantly altered after short time and low-dose treated with DEHP from 0.5 days post-coitum (dpc) to 3.5 dpc of pregnant mice. DNA methylation status of some neoplastic development genes, such as EGFr, Esr1, Pgr, Fos and Rassf5 also had no obvious change. These finding showed no impact of DEHP on the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in pregnant mouse mammary gland cells.
- Subjects :
- 0301 basic medicine
endocrine system
Health, Toxicology and Mutagenesis
Mammary gland
Public Health, Environmental and Occupational Health
Phthalate
Disease
Biology
Toxicology
medicine.disease
Pathology and Forensic Medicine
Andrology
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
medicine.anatomical_structure
Breast cancer
chemistry
DNA methylation
medicine
Epigenetics
General Pharmacology, Toxicology and Pharmaceutics
Estrogen receptor alpha
Gene
Subjects
Details
- ISSN :
- 20928467 and 1738642X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Molecular & Cellular Toxicology
- Accession number :
- edsair.doi...........2aff493fcfff4db89bd7dcfaa2db1ee7