Back to Search
Start Over
Identification and Characterization of an Idiopathic Pulmonary Fibrosis–Like Condition in Cats
- Source :
- Journal of Veterinary Internal Medicine. 18:632
- Publication Year :
- 2004
- Publisher :
- Wiley, 2004.
-
Abstract
- Interstitial lung diseases are a heterogeneous group of disorders with a variety of causes. In veterinary medicine, such lung diseases with a prominent fibrotic component of unknown etiology are often called idiopathic pulmonary fibrosis (IPF). In human medicine, this term is reserved for a distinct disease entity with specific histologic findings labeled as usual interstitial pneumonia (UIP). We identified 23 cats displaying histologic criteria of UIP The purpose of this retrospective study is to describe the presentation and response to therapy of these cats to better define this disease entity. All but 2 cats were middle aged to older (median 8.7 years), with no apparent sex or breed predisposition. Complaints included respiratory distress (n = 18) and cough (13). Duration of signs was less than 6 months in 17 cats. Physical-examination abnormalities included tachypnea, inspiratory or mixed inspiratory and expiratory effort, and adventitial lung sounds. No consistent hematologic or biochemical abnormalities, parasites, or positive serologic results for feline retroviruses, heartworms, or toxoplasmosis were present. Radiographic changes included dense patchy or diffuse interstitial, bronchiolar, and alveolar infiltrates. Analysis of bronchial lavage fluid revealed mild neutrophilic inflammation (n = 6) with no consistent pathogen growth. Clinical condition of 5 cats worsened after lavage. Coincident pulmonary neoplasia was identified in 6 cats. Response to therapy (corticosteroids, antibiotics, bronchodilators, and diuretics) was poor, and most cats died within days to months. Cats with histologic changes compatible with UIP had signs that mimicked many of the clinical findings of human IPF, and treatment response was similarly unrewarding.
- Subjects :
- Pathology
medicine.medical_specialty
CATS
Lung
General Veterinary
Respiratory distress
business.industry
Interstitial lung disease
respiratory system
medicine.disease
Tachypnea
respiratory tract diseases
Idiopathic pulmonary fibrosis
medicine.anatomical_structure
Usual interstitial pneumonia
Etiology
medicine
medicine.symptom
business
Subjects
Details
- ISSN :
- 08916640
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Veterinary Internal Medicine
- Accession number :
- edsair.doi...........2b15f19eaf8b82324b7151616d29dd0d
- Full Text :
- https://doi.org/10.1892/0891-6640(2004)18<632:iacoai>2.0.co;2