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Synthesis and Characterization of Camptothecin Intercalated into Mg/Al Layered Double Hydroxide
- Source :
- Chinese Journal of Chemistry. 26:1806-1810
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- The intercalation of camptothecin (CPT) into a layered inorganic host, Mg-Al layered double hydroxide (LDH), was carried out using a coprecipitation method to obtain CPT-LDH nanohybrids. It was found that the intercalated amounts (Ain) of CPT-LDH nanohybrids were remarkably dependent on the molar ratios (RC/M) of CPT to metal ions in raw materials. The Ain value increases with the RC/M value increasing. According to the gallery heights of CPT-LDH and sizes of CPT molecule, a probably morphology of CPT molecules in the gallery of LDH was suggested that the horizontal-arranged monolayer and vertical-arranged bilayer of CPT molecules coexisted in the interlayer region of LDH. An interesting result was found that the gallery height corresponding to the bilayer of CPT-LDH sample with a high Ain value was remarkably lower than that with low Ain value. The in vitro CPT release examinations from the nanohybrids showed that the CPT-LDH nanohybrids were a potential drug controlled release system. The kinetic analysis showed that the release kinetics of CPT from the nanohybrids obeyed the pseudo-first order kinetic model and the diffusion of CPT through the LDH particle of CPT played an important role in controlling the drug release rate.
- Subjects :
- endocrine system
endocrine system diseases
Chemistry
Coprecipitation
Metal ions in aqueous solution
Bilayer
Intercalation (chemistry)
Nanotechnology
General Chemistry
Controlled release
digestive system diseases
chemistry.chemical_compound
Monolayer
medicine
Hydroxide
heterocyclic compounds
neoplasms
Camptothecin
medicine.drug
Nuclear chemistry
Subjects
Details
- ISSN :
- 16147065 and 1001604X
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Chemistry
- Accession number :
- edsair.doi...........2be0201f94eec6f1227e9a7f349c16ba