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1034-P: Association between Estimated Glomerular Filtration Rate (eGFR) and Proteinuria (UP) to Predict Risk of Start of Dialysis in People with and without Diabetes (DM)
- Source :
- Diabetes. 70
- Publication Year :
- 2021
- Publisher :
- American Diabetes Association, 2021.
-
Abstract
- Although UP is a very important feature of diabetic nephropathy, decreased eGFR without UP has become phenotypic of renal complications of DM in the new definition of DKD. Although both UP and reduced eGFR are strong predictors of kidney disease, only a few studies have examined the association between these two variables and risk of dialysis in the same cohort that included people with and without DM. We analyzed data from a nationwide claims database involving 335,778 participants (DM 20,223, non-DM 315,555) during 2008-16. Multivariate Cox regression model identified risks of starting dialysis. HRs were compared among 8 groups of combinations of DM+/-, UP (-, ≥+) and eGFR ( In summary, both eGFR Disclosure T. Osawa: None. K. Fujihara: None. M. H. Yamada: None. Y. Yaguchi: None. T. Sato: None. M. Kitazawa: None. Y. Matsubayashi: None. T. Yamada: None. H. Sone: Research Support; Self; Astellas Pharma Inc., Eisai Co., Ltd., Kyowa Kirin Co., Ltd., Novo Nordisk, Ono Pharmaceutical Co., Ltd., Taisho Pharmaceutical Co., Ltd., Takeda Pharmaceutical Co. Funding Japan Society for the Promotion of Science (18K17897)
- Subjects :
- medicine.medical_specialty
Proteinuria
business.industry
Proportional hazards model
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Renal function
medicine.disease
Diabetic nephropathy
Diabetes mellitus
Internal medicine
Cohort
Internal Medicine
medicine
medicine.symptom
business
Dialysis
Kidney disease
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi...........2bff08d1e111380872ef8105b65f03ba