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Iridoid Glycosides and Phenolic Glycosides from Buddleja asiatica with Anti-inflammatory and Cytoprotective Activities
- Source :
- Natural Product Communications. 13:1934578X1801300
- Publication Year :
- 2018
- Publisher :
- SAGE Publications, 2018.
-
Abstract
- Chemical investigation of the methanol extract of the aerial parts of Buddleja asiatica resulted in the isolation of a new iridoid glycoside, buddlejasiaside A (1) and 11 known compounds: 6- O -[α-L-(4-isoferuloyl)-rhamnopyranosylcatalpol (2), specioside (3), verminoside (4), minecoside (5), 6- O -( p -hydroxybenzoyl)-ajugol (6), 6- O -caffeoyl ajugol (7), litanthosalin 8), eurostoside (9), 10- O -caffeoylaucubin (10), phlorizin (11), and garashangin (12). Their chemical structures were identified based on the MS and NMR spectroscopic analyses and comparing with the data reported in the literature. Compounds 1, 2, and 8-10 showed the modest inhibitory effects against nitrite production in LPS-stimulated BV2 microglia, with IC50 values ranging from 43.5-79.6 μM. Compounds 6, 7, and 11 protected HT22 hippocampal cells from glutamate-induced cell death, with EC50 values of 38.9, 14.8, and 27.1 μM, respectively.
- Subjects :
- Pharmacology
Iridoid Glycosides
chemistry.chemical_classification
biology
Iridoid
Buddlejaceae
Traditional medicine
010405 organic chemistry
medicine.drug_class
Chemistry
Glycoside
Plant Science
General Medicine
010402 general chemistry
biology.organism_classification
01 natural sciences
Anti-inflammatory
0104 chemical sciences
Complementary and alternative medicine
Drug Discovery
medicine
Buddleja asiatica
Subjects
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi...........2c97df0b64936417c53c50e575b5d5e1
- Full Text :
- https://doi.org/10.1177/1934578x1801300102