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Iridoid Glycosides and Phenolic Glycosides from Buddleja asiatica with Anti-inflammatory and Cytoprotective Activities

Authors :
Nguyen Xuan Nhiem
Hyuncheol Oh
Le Canh Viet Cuong
Bui Huu Tai
Phan Van Kiem
Pham Hai Yen
Duong Thi Hai Yen
Tran Hong Quang
Youn-Chul Kim
Truong Thi Thu Hien
Chau Van Minh
Source :
Natural Product Communications. 13:1934578X1801300
Publication Year :
2018
Publisher :
SAGE Publications, 2018.

Abstract

Chemical investigation of the methanol extract of the aerial parts of Buddleja asiatica resulted in the isolation of a new iridoid glycoside, buddlejasiaside A (1) and 11 known compounds: 6- O -[α-L-(4-isoferuloyl)-rhamnopyranosylcatalpol (2), specioside (3), verminoside (4), minecoside (5), 6- O -( p -hydroxybenzoyl)-ajugol (6), 6- O -caffeoyl ajugol (7), litanthosalin 8), eurostoside (9), 10- O -caffeoylaucubin (10), phlorizin (11), and garashangin (12). Their chemical structures were identified based on the MS and NMR spectroscopic analyses and comparing with the data reported in the literature. Compounds 1, 2, and 8-10 showed the modest inhibitory effects against nitrite production in LPS-stimulated BV2 microglia, with IC50 values ranging from 43.5-79.6 μM. Compounds 6, 7, and 11 protected HT22 hippocampal cells from glutamate-induced cell death, with EC50 values of 38.9, 14.8, and 27.1 μM, respectively.

Details

ISSN :
15559475 and 1934578X
Volume :
13
Database :
OpenAIRE
Journal :
Natural Product Communications
Accession number :
edsair.doi...........2c97df0b64936417c53c50e575b5d5e1
Full Text :
https://doi.org/10.1177/1934578x1801300102