Influenza Vaccination with 1/10th the Full Dose

To the Editor: As a result of the recent problems in the production of influenza vaccine, there is concern about whether the demand for vaccine will outstrip the supply for the upcoming influenza season.1 An ample vaccine supply is an ever-present concern, given the potential for future influenza pandemics and avian influenza.2 We recently evaluated 1/10th-dose influenza vaccine (Fluarix) as part of a larger phase 1b, randomized, controlled, double-blind vaccine study.3 Healthy volunteers (age range, 18 to 40 years) with negative results on screening tests of hemagglutination inhibition (HAI) for A/Beijing/262/95 and B/Harbin/7/94 were enrolled after they had given written . . .