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Isolation and pharmacological activities of bromophenols fromRhodomela confervoides
- Source :
- Chinese Journal of Oceanology and Limnology. 23:226-229
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- Four bromophenols were isolated from the extract of marine red alga,Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods inclding IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) bis (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4) 3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities againstStaphylococcus aurens andPseudomonas aeruginosa.
Details
- ISSN :
- 19935005 and 02544059
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Oceanology and Limnology
- Accession number :
- edsair.doi...........2d5d513e70e1c16a88f546d06000abc6