In Vitro and In Vivo Immunomodulatory Activities of an Acidic Polysaccharide from Gracilaria lemaneiformis

The effects of an acidic polysaccharide from Gracilaria lemaneiformis (GLSPs) on the immunomodulation in vitro and in vivo were investigated. It was shown that GLSPs with different concentrations significantly promoted the splenocyte proliferation and macrophage phagocytosis in vitro. In addition, GLSPs also remarkably enhanced the splenocyte proliferation induced by ConA or LPS in mice, notably improved the macrophage phagocytosis towards neutral red, and increased the percentages of CD3+ and CD4+ cells in peripheral blood of mice. The results suggested that GLSPs has significant effect on immunomodulation, and may have biomedical material applications and potential use in stimulating the immune system.