AUTOLOGOUS PLATELET - RICH PLASMA (PRP) THERAPY AND CHANGEMENTS OF TOPICAL BIOLOGICAL MARKERS (EGF, VEGF AND MMP12) OF CHRONIC WOUNDS

Objective: Our aim was to evaluate topical EGF, VEGF, MMP12 concentrations of ​​chronic wounds which after Autologous Platelet - Rich Plasma(PRP) therapy. Methods: The study conducted a descriptive longitudinal study at the Wound Healing Center of the Vietnam National Burn Hospital from 11/2018 to 2/2020. 24 patients with chronic wounds and aged 18 years old or older were enrolled in this study. These patients were injected autologous PRP at wound bed. We biopsied chronic wound bed tissue for evaluating EGF, VEGF and MMP12 by the Elisa technique at the first, second and third week of follow-up. Results: After PRP therapy, topical EGF and VEGF concentration increased after 1 week of treatment. MMP12 concentraiton significantly reduced compaired to before PRP therapy. Conclusion: In addition to PRP therapy had a beneficial effect on cutaneous regeneration and wound healing of the chronic wound. The autologous PRP promoted the wound healing process byincreating topical EGF and VEGF, reducing MMP12 which known as a pro-inflammatiory mediator.