Back to Search
Start Over
Measurement of extracellular volume and transit time heterogeneity using contrast-enhanced myocardial perfusion MRI in patients after acute myocardial infarction
- Source :
- Magnetic Resonance in Medicine. 77:2320-2330
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Purpose To assess the ability of dynamic contrast-enhanced myocardial perfusion MRI to measure extracellular volume (ECV) and to investigate the possibility of estimating capillary transit time heterogeneity (CTH) in patients after myocardial infarction and successful revascularization. Methods Twenty-four perfusion data sets were acquired on a 3 Tesla positron emission tomography (PET)/MRI scanner. Three perfusion models of different complexity were implemented in a hierarchical fashion with an Akaike information criterion being used to determine the number of fit parameters supported by the data. Results were compared sector-wise to ECV from an equilibrium T1 mapping method (modified look-locker inversion recovery (MOLLI)). Results ECV derived from the perfusion analysis correlated well with equilibrium measurements (R² = 0.76). Estimation of CTH was supported in 16% of sectors (mostly remote). Inclusion of a nonzero CTH parameter usually led to lower estimates of first-pass extraction and slightly higher estimates of blood volume and flow. Estimation of the capillary permeability-surface area product was feasible in 81% of sectors. Conclusion Transit time heterogeneity has a measurable effect on the kinetic analysis of myocardial perfusion MRI data, and Gd-DTPA extravasation in the myocardium is usually not flow-limited in infarct-related pathology. Measurement of myocardial ECV using perfusion imaging could provide a scan-time efficient alternative to methods based on T1 mapping. Magn Reson Med 77:2320–2330, 2017. © 2016 International Society for Magnetic Resonance in Medicine
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
business.industry
medicine.medical_treatment
Perfusion scanning
Magnetic resonance imaging
Blood volume
030204 cardiovascular system & hematology
Revascularization
Magnetic resonance angiography
030218 nuclear medicine & medical imaging
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Positron emission tomography
Internal medicine
Cardiology
Medicine
Radiology, Nuclear Medicine and imaging
business
Nuclear medicine
Perfusion
Subjects
Details
- ISSN :
- 07403194
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance in Medicine
- Accession number :
- edsair.doi...........2ee8d9a769f6b999b808ac0c085b7bbd