A novel non-enzymatic glucose sensor based on a Cu-nanoparticle-modified graphene edge nanoelectrode

A novel, stable and sensitive non-enzymatic glucose sensor was developed by potentiostatically electrodepositing metallic Cu nanoparticles on a linear graphene edge nanoelectrode (Cu–GNE). The electrochemical performance of the Cu–GNE for the detection of glucose was investigated by cyclic voltammetry and chronoamperometry. The Cu–GNE displayed a synergistic effect of copper nanoparticles and the edge plane of the graphene sheet towards the oxidation of glucose in alkaline solution, showing a large oxidation current and negative shift in peak potential. At a detection potential of 0.5 V, the Cu–GNE sensor exhibited a wide linear range up to 1 mM glucose, with a detection limit of 0.12 μM (S/N = 3). In addition, the sensor responded very quickly (