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IS ATHEROSCLEROSIS EXCLUSIVELY A POSTPRANDIAL PHENOMENON?

IS ATHEROSCLEROSIS EXCLUSIVELY A POSTPRANDIAL PHENOMENON?

Authors :
Melanie Voevodin
Spencer D. Proctor
John C.L. Mamo
Darrin Smith
Donna F. Vine
Caryn L. Elsegood
Kenneth C.-W. Yu
Hanni C. Gennat
Source :
Clinical and Experimental Pharmacology and Physiology. 24:288-293
Publication Year :
1997
Publisher :
Wiley, 1997.

Abstract

SUMMARY 1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many articles that deal with various aspects of LDL metabolism. 2. Postprandial lipoproteins (i.e. chylomicrons transporting dietary fats) are also considered pro-atherogenic; however, it is less clear whether their involvement in arterial cholesterol deposition is direct or follows modulation of LDL metabolism. 3. In order to provoke discussion, this article is presented in a manner that suggests atherosclerosis to be exclusively a postprandial phenomenon; that is, we have raised the possibility that LDL is non-atherogenic.

Details

ISSN :
14401681 and 03051870
Volume :
24
Database :
OpenAIRE
Journal :
Clinical and Experimental Pharmacology and Physiology
Accession number :
edsair.doi...........2f0cab5431e04dc31fe84e22708d75c4
Full Text :
https://doi.org/10.1111/j.1440-1681.1997.tb01822.x