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IS ATHEROSCLEROSIS EXCLUSIVELY A POSTPRANDIAL PHENOMENON?
IS ATHEROSCLEROSIS EXCLUSIVELY A POSTPRANDIAL PHENOMENON?
- Source :
- Clinical and Experimental Pharmacology and Physiology. 24:288-293
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- SUMMARY 1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many articles that deal with various aspects of LDL metabolism. 2. Postprandial lipoproteins (i.e. chylomicrons transporting dietary fats) are also considered pro-atherogenic; however, it is less clear whether their involvement in arterial cholesterol deposition is direct or follows modulation of LDL metabolism. 3. In order to provoke discussion, this article is presented in a manner that suggests atherosclerosis to be exclusively a postprandial phenomenon; that is, we have raised the possibility that LDL is non-atherogenic.
- Subjects :
- Pharmacology
medicine.medical_specialty
Physiology
Cholesterol
business.industry
Circulating Lipoproteins
Blood lipids
Cholesterol deposition
chemistry.chemical_compound
Postprandial
Endocrinology
chemistry
Physiology (medical)
Internal medicine
Ldl metabolism
Low-density lipoprotein
medicine
lipids (amino acids, peptides, and proteins)
business
Chylomicron
Subjects
Details
- ISSN :
- 14401681 and 03051870
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Pharmacology and Physiology
- Accession number :
- edsair.doi...........2f0cab5431e04dc31fe84e22708d75c4
- Full Text :
- https://doi.org/10.1111/j.1440-1681.1997.tb01822.x