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H2S signaling and extracellular matrix remodeling in cardiovascular diseases: A tale of tense relationship
- Source :
- Nitric Oxide. 116:14-26
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network that not only provides mechanical support but also transduces essential molecular signals in organ functions. ECM is constantly remodeled to control tissue homeostasis, responsible for cell adhesion, cell migration, cell-to-cell communication, and cell differentiation, etc. The dysregulation of ECM components contributes to various diseases, including cardiovascular diseases, fibrosis, cancer, and neurodegenerative diseases, etc. Aberrant ECM remodeling is initiated by various stress, such as oxidative stress, inflammation, ischemia, and mechanical stress, etc. Hydrogen sulfide (H2S) is a gasotransmitter that exhibits a wide variety of cytoprotective and physiological functions through its anti-oxidative and anti-inflammatory actions. Amounting research shows that H2S can attenuate aberrant ECM remodeling. In this review, we discussed the implications and mechanisms of H2S in the regulation of ECM remodeling in cardiovascular diseases, and highlighted the potential of H2S in the prevention and treatment of cardiovascular diseases through attenuating adverse ECM remodeling.
- Subjects :
- 0303 health sciences
Cancer Research
Physiology
Cellular differentiation
Clinical Biochemistry
Cell migration
Inflammation
030204 cardiovascular system & hematology
Biology
medicine.disease_cause
medicine.disease
Biochemistry
3. Good health
Cell biology
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
Fibrosis
medicine
medicine.symptom
Cell adhesion
Oxidative stress
Tissue homeostasis
030304 developmental biology
Subjects
Details
- ISSN :
- 10898603
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- Nitric Oxide
- Accession number :
- edsair.doi...........2f38ea3f91f49120073ea00c89494371