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A review on recent advances for nucleants and nucleation in protein crystallization
- Source :
- CrystEngComm. 19:1143-1155
- Publication Year :
- 2017
- Publisher :
- Royal Society of Chemistry (RSC), 2017.
-
Abstract
- The elucidation of protein structures by X-ray crystallography remains the most effectual method to provide accurate structural details at atomic resolution for rational drug design and other biotechnological research studies. Also, emerging applications of protein crystals as ordered nanostructure scaffolds for catalysis, imaging, and drug delivery are attracting much attention. However, the first step of these applications is obtaining high-quality crystals, which is still an obstacle. Successful crystallization requires two steps: nucleation and crystal growth, while the nucleation is a precondition for harvesting the crystal of interest. So controlling protein nucleation may be an alternative breakthrough for this bottleneck. It is well known that nucleants can induce protein crystallization and improve crystal quality, so investigation on the nucleants that can be universally used for any protein crystallization is ongoing. This manuscript reviews the advances that have been achieved using nucleants in protein crystallization and it is a suitable reference for practical crystallization.
- Subjects :
- Materials science
Nucleation
Drug design
Nanotechnology
Crystal growth
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
law.invention
Crystal
Protein structure
law
Drug delivery
General Materials Science
Crystallization
0210 nano-technology
Protein crystallization
Subjects
Details
- ISSN :
- 14668033
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- CrystEngComm
- Accession number :
- edsair.doi...........2f52637b600af675a464b9b6949921b1