ChemInform Abstract: Nitrile Imines: Versatile Intermediates in the Synthesis of Five Membered Heterocycles

Nitrile imines are considered as the versatile reactive intermediates and are recognized as a linear-type 1,3-dipoles extensively used in 1,3-dipolar cycloaddition reactions for constructing biologically potent five membered heterocycles. This review article comprises the brief history, up to date information about the various methods employed for the generation, stability, reactivity and synthetic applications of nitrile imines. The stereochemistry of the products formed with the use of nitrile imines and biological activity associated with the cycloadducts formed was also presented.