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Development of a Robust and Scalable Process for the Large-Scale Preparation of Vadadustat

Authors :
Zhongqing Wang
Xiao Qingbo
Li Yinglong
Shuming Wu
Hu Ji'an
Jianbing Li
Lin Biyue
Jingping Kou
Xuerong Cai
Source :
Organic Process Research & Development. 25:960-968
Publication Year :
2021
Publisher :
American Chemical Society (ACS), 2021.

Abstract

A novel and scalable process is developed for the industrial synthesis of vadadustat. The four-step process is one step shorter compared to the reported routes with an increase in total yield to 49...

Details

ISSN :
1520586X and 10836160
Volume :
25
Database :
OpenAIRE
Journal :
Organic Process Research & Development
Accession number :
edsair.doi...........2fc48b05fe5f185c8fe439394d0aee81
Full Text :
https://doi.org/10.1021/acs.oprd.1c00004