120-OR: Diabetes-Related Quality of Life Assessment in Children following Total Pancreatectomy with Islet Autotransplantation

Total pancreatectomy with islet autotransplantation (TPIAT) can effectively improve pain and functional impairment associated with chronic pancreatitis (CP) in children. However, children undergoing this procedure usually develop post-pancreatectomy diabetes and require chronic insulin therapy. It can be difficult for providers and patients to conceptualize trading the symptoms of CP for the burden of diabetes. Therefore, we sought to evaluate diabetes-related quality of life (QOL) over time in children who underwent TPIAT, and compare QOL scores post-TPIAT with children who have type 1 diabetes (T1D). The Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module was used to assess diabetes-related QOL. PedsQL scores were evaluated in 46 children (0.2). The Total PedsQL score, mostly attributable to the Diabetes Symptoms subscale, decreased over time in patients who underwent TPIAT. Additionally, diabetes-related QOL at 24 months was not significantly different from children with T1D. This data may be used to help counsel families who are considering TPIAT for treatment of CP. Disclosure J.M. Redel: None. L. Hornung: None. D.A. Elder: None. J.D. Nathan: None. M. Abu-El-Haija: None. Funding Cincinnati Children’s Hospital