Small fiber neuropathy in late-onset Pompe disease: a case report and prospective screening

compared with detailed physical testing of the same muscle groups. MR showed improved sensitivity for detection of abnormality in multiple muscle groups including those producing ankle eversion and dorsiflexion, knee flexion and extension, tongue movement, neck extension, elbow flexion and extension, andmost of the isolated movements of the shoulder. Color-codedmuscle map images were then generated to serve as clinical tools for display of complimentary MR and physical examination data and to facilitate more rapid interpretation of the dataset. We believe this integrated, quantitative approach to muscle group assessment will prove both robust and clinically useful in tracking progression and response to treatment in Pompe disease and other neuromuscular disorders.