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Evaluation of Ficus retusa L. Leaves with Special Reference to Antidiarrheal and Anti-spasmodic Activity
- Source :
- Current Drug Discovery Technologies. 18:120-126
- Publication Year :
- 2021
- Publisher :
- Bentham Science Publishers Ltd., 2021.
-
Abstract
- Aims: The aim of present investigation was to evaluate the traditional claim of Ficus retusa as an anti-diarrheal and anti-spasmodic agent using different pharmacological models. Background: Diarrhea is considered as major cause of mortality, especially in children and aged persons. Because of diarrhoea, 17% of admitted children get die. In order to treat the diarrhea, natural drugs may be useful. Objective: In order to prove the traditional claim of Ficus retusa, present work was undertaken with objective to prove antidiarrheal and antispasmodic activity. Methods: The anti-diarrhoeal activity was evaluated by magnesium sulphate induced diarrhea and 5-hydroxy tryptamine(5HT) induced diarrhea. Further, the exact were subjected to gastrointestinal motility test using standard procedure. Conclusion: The response towards bioactivity was dose dependent. It was concluded that 400mg/kg bw of ethanolic extract is most potent in antidiarrhoeal and antispasmodic activity.
Details
- ISSN :
- 15701638
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Current Drug Discovery Technologies
- Accession number :
- edsair.doi...........315ee2bce173dc61d7bca7a33a9d1a04
- Full Text :
- https://doi.org/10.2174/1570163817666200128100631