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P1‐106: Anxiety is related to Alzheimer's disease markers in cerebrospinal fluid of subjects with mild cognitive impairment

Authors :
Leslie M. Shaw
Pauline Aalten
Philip Scheltens
M.M. Verbeek
Inez H.G.B. Ramakers
Harald Hampel
Marcel Olde Rikkert
Hilkka Soininen
Luiza Spiru
John Q. Trojanowski
Kaj Blennow
F.R.J. Verhey
Adni
Pieter Jelle Visser
Source :
Alzheimer's & Dementia. 7
Publication Year :
2011
Publisher :
Wiley, 2011.

Abstract

in both anterior temporal lobes while FDG PET scan showed posterior hypofixation atypical for AD. The CSF of tau-protein (600 pg/ml), phosphorylated tau (87 pg/ml) were increased, whereas the concentration of beta-amyloid protein (Abeta1-42) was decreased (480 pg/ml) according to our cut-off (Dumurgier et al.) suggesting AD CSF profile. Conclusions: Among different clinical AD phenotype, FTD clinical presentation must not be misdiagnosed. CSF biomarkers are helpful to diagnose these patients, establish an accurate diagnosis and introduce a specific treatment.

Details

ISSN :
15525279 and 15525260
Volume :
7
Database :
OpenAIRE
Journal :
Alzheimer's & Dementia
Accession number :
edsair.doi...........3179b14506c3878cad1e2d0db8035048
Full Text :
https://doi.org/10.1016/j.jalz.2011.05.385