ChemInform Abstract: New Class of Potent Ligands for the Human Peripheral Cannabinoid Receptor

Authors :: C. Rochette
Yves Gareau
Marc Labelle
Deborah Slipetz
Kathleen M. Metters
Nathalie Tremblay
Claude Dufresne
Michel Gallant
Yves Leblanc
P. Prasit
Daniel Guay
Nicole Sawyer
Source :: ChemInform. 28
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: A new class of potent ligand for the human peripheral cannabinoid (hCB 2 ) receptor is described. Two indole analogs 13 and 17 exhibited nanomolar potencies (K i ) with good selectivity for the hCB 2 receptor over the human central cannabinoid (hCB 1 ) receptor.

Subjects :: Indole test
Cannabinoid receptor
Chemistry
Stereochemistry
Ligand
medicine.medical_treatment
medicine
General Medicine
Cannabinoid
Receptor
Peripheral

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