A new synthesis of angularly substituted bicyclic systems via an anionic oxy-cope rearrangement

Authors :: Panayencheri C. Srinivasan
S. Swaminathan
G. Sathyamoorthi
K. Thangaraj
Source :: Tetrahedron. 46:3559-3568
Publication Year :: 1990
Publisher :: Elsevier BV, 1990.
Abstract: A general synthesis of trans bicyclic carbinols with an angular methyl substituent using the anionic oxy-Cope rearrangement is reported. The carbinols 13a , l3b , 14a , 14b and 15 furnish the bicyclic carbinols 16a , 16b 17a , 17b and 18 when treated with potassium hydride in 1,2-dimethoxyeth ane.

Subjects :: chemistry.chemical_compound
Bicyclic molecule
chemistry
Stereochemistry
Potassium hydride
Organic Chemistry
Drug Discovery
Substituent
Oxy-Cope rearrangement
Biochemistry
Medicinal chemistry

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