Back to Search
Start Over
OCT angiography analysis of choriocapillaris vascular density in different stages of age-related macular degeneration
- Source :
- Frontiers in Ophthalmology. 2
- Publication Year :
- 2022
- Publisher :
- Frontiers Media SA, 2022.
-
Abstract
- ObjectivesTo analyze the choriocapillaris vessel density (CVD) of eyes at different stages of Age-related Macular Degeneration (AMD) with Optical Coherence Tomography Angiography (OCTA).MethodsThis is a prospective observational cross-sectional study on 21 age-matched healthy eyes and 84 eyes with AMD (i.e., early AMD, late AMD, Geographic Atrophy [GA], and disciform scar AMD). OCTA was used to automatically measure the CVD (%), on both the whole macula and the foveal area, in a layer going from 9 µm above to 30 µm below the Bruch’s membrane. Furthermore, in the GA subgroup, the extension of the Ellipsoid Zone (EZ) interruption and the area of macular chorio-retinal atrophy was analyzed.ResultsMacular CVD was significantly lower in the GA, late AMD and disciform scar AMD-subgroups compared to controls (respectively, p=0.0052; pConclusionsOCTA could play a crucial role in the categorization of AMD, allowing for the evaluation of gradual flow impairment at different stages of the disease. Moreover, the detection of a decreased macular and foveal CVD may shed light on the pathogenesis of AMD.
Details
- ISSN :
- 26740826
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Frontiers in Ophthalmology
- Accession number :
- edsair.doi...........3404cc4a22046f6472994abe018ec385