Association of Anti Mullerian Hormone with Biochemical markers in womens with and without Polycystic Ovarian disease

Introduction: The frequency of polycystic ovarian syndrome (PCOS) has come to nearly epidemic extents in ladies of reproductive age around the world. Polycystic ovarian syndrome is one of the foremost common endocrinological problems in ladies. In expansion to chronic oligo-anovulation, the fundamental highlights of the PCOS incorporate raised levels of circulating androgens or clinical hyperandrogenism, polycystic ovary morphology, modified gonadotropin secretion, insulin resistance and compensatory hyperinsulinemia frequently related with obesity. Objective: The purpose of this study was to compare the affiliations of anti-Müllerian hormone (AMH) with biochemical characteristics between ladies with and without polycystic ovary syndrome (PCOS). Material & Method: Study design: Quantitative cross sectional Settings: Lady Wallington Hospital Lahore Duration: Six months i.e. 1st July 2021 to 31st December 2021 Methodology: Quantitative cross sectional study was performed at lady Wallington hospital Lahore. The total numbers of patients were 150. Age of females was in between 18-35 years. The diagnosis of polycystic ovarian syndrome was made according to the Rotterdam ESHRE-ASRM criteria. The various parameters which include Body mass index, lipid profile, Blood sugar levels, FSH, LH, Prolactin, testosterone levels, AMH DHEA-S, HOMA-IR and adiponectin were measured. Collected data was entered in SPSS version 23 and analyzed. Results: Data for females with PCOS and control summarized briefly in table no 1. AMH level have significant p value 0.001 and clearly showed that it is higher in females with PCOS whether fatty or non-fatty than normal or control. Conclusion: In conclusion, AMH levels were essentially higher in ladies with PCOS, in any case of age and BMI, and exhibited no relationship with obesity, insulin resistance, or metabolic syndrome-related factors. Only testosterone shown an impact on serum AMH levels in PCOS group, whereas age, adiponectin as well as testosterone altogether related with AMH levels within the control group. Keywords: Polycystic ovarian syndrome, AMH, Gonadotrophin, TSH, Insulin