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A phase I/II study of the combination of indoximod and temozolomide for adult patients with temozolomide-refractory primary malignant brain tumors
- Source :
- Journal of Clinical Oncology. 32:TPS2107-TPS2107
- Publication Year :
- 2014
- Publisher :
- American Society of Clinical Oncology (ASCO), 2014.
-
Abstract
- TPS2107 Background: Indoleamine 2, 3-dioxygenase (IDO) is a key immune-modulatory endogenous enzyme that inhibits CD8+ T cells and enhances the suppressor activity of Tregs. IDO is expressed in a l...
- Subjects :
- chemistry.chemical_classification
Cancer Research
Temozolomide
Adult patients
business.industry
chemical and pharmacologic phenomena
Endogeny
law.invention
Enzyme
Oncology
chemistry
Refractory
law
Immunology
Primary Malignant Brain Tumors
medicine
Cancer research
Suppressor
business
CD8
medicine.drug
Subjects
Details
- ISSN :
- 15277755 and 0732183X
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Oncology
- Accession number :
- edsair.doi...........346a4ce3f0812af7fabfe3c81ced48f8
- Full Text :
- https://doi.org/10.1200/jco.2014.32.15_suppl.tps2107