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Copper-catalyzed regio- and stereoselective fluorocarboalkynylation of alkynes
- Source :
- Organic Chemistry Frontiers. 8:6857-6862
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- It is attractive to establish an efficient and practical platform affording functional compounds using readily available feedstocks as starting materials under mild conditions. We describe a direct copper-catalyzed fluorocarboalkynylation of the readily available alkynes with excellent regio- and stereoselectivity. A wide range of conjugated trifluoromethyl 1,3-enynes were obtained in good yields by this operationally simple strategy. The mechanistic experiments and DFT calculation revealed that a radical-mediated process was involved in the catalytic cycle.
Details
- ISSN :
- 20524129
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Organic Chemistry Frontiers
- Accession number :
- edsair.doi...........347a450ceb18f827735206fe39e5d4e1