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Albumin levels as a biomarker for second Intravenous Immunoglobulin (IVIG) treatment in Guillain-Barre syndrome (GBS)

Authors :
Shiri Savir
Moti Klein
Yoav Bichovsky
Andrey Ovanyan
Anna Shalman
Evgeni Brotfain
Alexander Zlotnik
Leonid Koyfman
Yana Mechnik Steen
Nancy Boniel
Source :
Journal of Clinical Neuroscience. 74:247-249
Publication Year :
2020
Publisher :
Elsevier BV, 2020.

Abstract

Background Patients with GBS may develop hypoalbuminemia following treatment with Intravenous Immunoglobulin (IVIG), which is related to a poorer outcome. This report presents a patient with GBS and his clinical response to two courses of IVIG treatments in association with his albumin level. Case report: A previously healthy 21-year-old male was admitted to the GICU due to GBS with severity grade 5 (required assisted ventilation). IVIG treatment was initiated. Over the next two weeks there was no clinical improvement and Albumin level dropped from 4.5 gr/dL to a nadir of 2.3 gr/dL. A second course of IVIG was initiated. After initiation of the second course the patient’s albumin began rising to 3.0 gr/dL and a clinical improvement followed this rise. Subsequently, he was weaned from mechanical ventilation within a few days. Conclusions When considering a second course of IVIG treatment, serum albumin levels may be considered a biomarker as part of the decision algorithm.

Details

ISSN :
09675868
Volume :
74
Database :
OpenAIRE
Journal :
Journal of Clinical Neuroscience
Accession number :
edsair.doi...........34f260cde38712dee21dba9ff07ac4f6