Immunological Profile of Iraqi Atopic Patients

The aims of the study are determine some immunological aspects namely total IgE, specific IgE, eosinophil count, IFN-γ, IL-10 and CCL-17 in serum of atopic patients and apparently healthy control to determine their relationship to atopic diseases. The age group of 21–40 years seems to be the most affect group with atopic diseases (P =0.0001) and asthmatic and allergic rhinitis patients are at this age group also (P =0.005, P =0.001respectively). There is a major differences (P < 0.001) in level of total IgE between allergic subjects and controls and among three atopic patients groups (P < 0.001) but Specific IgE is significantly higher in asthmatics than allergic rhinitis and atopic dermatitis patients (P < 0.05). Inhalation of outdoor allergens is significantly affected asthmatic patients and allergic rhinitis patients (P < 0.01). Controversially, indoor allergens are significantly affecting atopic dermatitis (P < 0.01). The mean of IFN-γ serum level in asthma patients was lower than IFN-γ serum level of the control group and atopic dermatitis patients (P < 0.05). The allergic rhinitis patients mean of serum level of IL-10 was significantly low as compared to the mean of the serum level of IL-10 control group (P= 0.020). All of three groups of atopic patients are significantly have high level of CCL-17 compare to mean of serum level of control group (P < 0.01).